sophora flavescens chinese medicine

Matrine and oxymatrine are two of the major phytochemical … Sophora flavescens protects against mycobacterial Trehalose Dimycolate-induced lung granuloma by inhibiting inflammation and infiltration of macrophages. AIM AND OBJECTIVE:Five-Flavor Sophora flavescens Enteric-Coated Capsules (FSEC) are the only proprietary Chinese medicine approved for the treatment of ulcerative colitis (UC) in China. China Sophora Flavescens Root Extract manufacturers - Select 2020 high quality Sophora Flavescens Root Extract products in best price from certified Chinese Natural Plant Extract manufacturers, Herbal Extract Powder suppliers, wholesalers and factory on Made-in-China.com Sophora flavescens functions by influencing the heart, liver, stomach, large intestine and bladder. 100 A.D.). Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. It was recently reported that SF up-regulates CYP3A expression. The mechanism of SF-induced CYP3A expression is unknown. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Disclaimer: The Ben Cao Medical Book is translated by ChinaAbout.net. Compiled and written by Li Shi-zhen (1518~1593), a medical expert of the Ming Dynasty (1368-1644) over 27 years. Your email address will not be published. The data are presented as means (n 3 at each concentration). The Ben Cao Medical Book (also known as Compendium of Materia Medica or Ben Cao Gang Mu; Chinese: 本草纲目) is the most famous and comprehensive medical book ever written in the history of traditional Chinese medicine (TCM). Required fields are marked *. In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. Compounds in Sophora flavescens possessing medicinal properties include oxymatrine, matrine and sophoridine. Ku shen or kushenin is a typical traditional Chinese medicine that is found in this plant. Some features of the site may not work correctly. DPX2 cells were incubated for 24 h with individual chemicals identified from SF aqueous extract. Haglund, Coix lacryma-jobi L., Smilax glabra Roxb., Sanguisorba officinalis L, Styphnolobium japonicum (L.) Schott, Prunus persica (L.) Batsch, Sophora flavescens Aiton, and Eupolyphaga sinensis Walker. About fifteen of these species have a long history of use in traditional Chinese medicines. Sophora flavescens is a species of plant in the genus ''Sophora''. Change the quantity to reflect how many ounces youd like. Ku Shen or Radix Sophorae Flavescentis is more commonly known as Sophora Root and is a herb that clean the heat. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Sophora flavescens, the shrubby sophora, is a species of plant in the genus Sophora of the family Fabaceae. A decoction of root of sophora flavescens is applied on affected part to treat eczema, pruritus, scabies and colpitis. Sophora (see Figure 2) was first described in the Shennong Bencao Jing (ca. Select Your Cookie Preferences. It was recently reported that SF up-regulates CYP3A expression. The book reflects the pharmaceutical achievements and developments of East Asia before the 16th century. Regulation of cyp3a gene transcription by the pregnane x receptor. Sophora falvescens (Ku shen) contains a variety of matrine alkaloids, such as aloperine, cytosine, lehmannine, matrine, oxymartine, oxysophocarpine, sophocarpine, sophoramine, and sophoridine, the flavonoid kushenol, and the saponin sophoraflavoside. The root known as “Ku Shen” which means “bitter root” in Chinese, has been used in Traditional Medicine for two thousand years to treat a variety of conditions, including diarrhea, jaundice, skin rashes, and to kill parasites. Although the chemical constituents have been clarified by our previous studies, the metabolic transformation of “Dogel ebs” in vivo was still unclear. In the current study, we tested the hypothesis that SF-induced CYP3A expression is mediated by the activation of pregnane X receptor (PXR). Copyright©2013 – 2019 ChinaAbout.net, About Us | Cookies Notice | Site Map |Privacy Policy |. Anti-inflammatory and anti-arthritic activity of total flavonoids of the roots of Sophora flavescens. English; Chinese; CONTACT US: +44 (0) 1245 350822. Reseeds, perennial. Effects of matrine and oxymatrine on catalytic activity of cytochrome p450s in rats. It is an aqueous extract of a Chinese herbal formula primarily consisting of eight TCM herbs: Taraxacum campylodes G.E. A new compound, kushenol Z (KZ), and 14 known flavonoids were isolated from SF. Impact of the Herbal Medicine Sophora flavescens on the Oral Pharmacokinetics of Indinavir in Rats: The Involvement of CYP3A and P-Glycoprotein. The mechanism of SF-induced CYP3A expression is unknown. Pioneering the development of Chinese medicine. In the current study, we tested the hypothesis that SF-induced CYP3A expression is … It is commonly used for the treatment of viral hepatitis, enteritis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. 4. Sophora flavescens root is known as Ku Shen in traditional Chinese medicine. It serves as a bitter tonic, diuretic and also helps to treat skin diseases such as eczema and pruritus. The pregnane X receptor: from bench to bedside. Sophora flavescens (Fabaceae), also known as Kushen (Chinese: 苦参), has been an important species in Chinese medicine since the Qin and Han dynasties. Sophora flavescens (syn. You are currently offline. This genus contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceania, and the Pacific islands. The flavonoids of Sophora flavescens exerts anti‐inflammatory activity via promoting autophagy of ... Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants, The Chinese University of Hong Kong, Hong Kong, China . The Ben Cao Medical Book records and describes all the plants, animals, minerals, and other objects that were believed to have medicinal properties in TCM. Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. Induction of cytochrome P450 3A by Shexiang Baoxin Pill and its main components. This is just one more way of ensuring your safety and that of our staff. What is Sophora Flavescens Extract Matrine Oxymatrine? ← Dictamnus Albus Root As Medicine – Ben Cao Medical Book, Cimicifuga Rhizoma As Medicine – Ben Cao Medical Book →, 5 Health Benefits of Soju - Ben Cao Medical Book, Health Benefits of Rubus Chingii - Ben Cao Medical Book, 4 Amazing Health Benefits of Pistachios - Ben Cao Medical Book, 4 Health Benefits of Cuscuta Chinensis - Ben Cao Medical Book, Health Benefits of Dioscorea Bulbifera - Ben Cao Medical Book, 5 Amazing Uses And Health Benefits of Lotus Leaves - Ben Cao Medical Book, Barn Swallows’ Mud Nest As Medicine – Ben Cao Medical Book, Bees’ Nest As Medicine – Ben Cao Medical Book, Dung Balls As Medicine – Ben Cao Medical Book. Sophora flavescens is a species of plant in the genus Sophora. It is intended as a sharing of CTM knowledge and information from the research and experience from the author Li Shi-zhen. Pills made with dried root of sophora flavescens and honey is taken with mint soup to treat high-grade fevers. Ku shen is a Chinese herbal remedy made from the root of S. falvescens. Dehua Liu. Institute of Chinese Medicine and State Key … Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. The mechanism of SF-induced CYP3A expression is unknown. Charles Darwin, originator of the biological theory of evolution, regards the book as the “ancient Chinese encyclopedia”. If you continue to use this site we will assume that you are happy with it. Search for more papers by this author. Ethnopharmacological relevance. Sophora flavescens is the primary component of Equilibrant, an oxymatrine-based … Avoid taking veratrum nigrum root and root of sophora flavescens at the same time; Patients with deficiency and cold in spleen or stomach should not take medicine that contains root of sophora flavescens. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Notify me of follow-up comments by email. "Anti-inflammatory and anti-oxidant effec… The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. The roots of Sophora flavescens (SF) are clinically used as a traditional Chinese medicine for the treatment of various lung diseases. Inhibition of Cytochrome P450 Activities by Sophora flavescens Extract and Its Prenylated Flavonoids in Human Liver Microsomes. Dispensary Register/Log In; Language: English. In this study the herb-drug interactions between S. flavescens and indinavir, a protease inhibitor for HIV treatment, were evaluated in rats. Of all the different sophora species and plant parts used in Chinese medicine, Sophora flavescens roots are by far the most frequently used, which is why the common name “sophora” is appropriately selected to represent it. 1 oz: $20.00 Want more than 1 ounce? Sophora flavescens (SF) is an herbal medicine widely used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage, and skin diseases. With this in mind, we’ve put in place many new procedures, including a limited visitor policy. Ku shen (the root) or kushenin (a flavonoid compound) is a typical traditional chinese medicine that is found in this plant. This plant often grows on hillsides, grass slopes, or … Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats, PXR: a center of transcriptional regulation in cancer, Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR, The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes, The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway, Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells. Sophora flavescens is a species of plant in the genus Sophora a genus of the Fabaceae family, that contains about 52 species, nineteen varieties, and seven forms that are widely distributed in Asia, Oceanica, and the Pacific islands.About fifteen species in this genus have a long history of use in traditional Chinese medicines. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. It was recently reported that SF up-regulates CYP3A expression. Sophora flavescens is a deciduous shrub related to peas. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. Entering meridians include the Urinary Bladder, Heart, Liver, Large Intestine, Stomach and Small Intestine. Sophora has anti-inflammatory and antioxidant properties.1 Sophora flavescens may have the potential for treatment of chronic inflammatory disorders such as rheumatoid arthritis.2 Sophora could possibly be used as a treatment for mast cell-derived allergic inflammatory diseases.3 Sophora may be an effective cholesterol-lowering agent and useful for preventing hypercholesterolemic atherosclerosis.4 Sources: 1. Sophora flavescens | Memorial Sloan Kettering Cancer Center We're committed to providing you with the very best cancer care, and your safety continues to be a top priority. Author information: (1)Institute of Chinese Medicine, The Chinese University of … Liu D(1)(2), Chan BC(1)(2), Cheng L(1)(2), Tsang MS(1)(2), Zhu J(3), Wong CW(1)(2), Jiao D(3), Chan HY(3), Leung PC(1)(2), Lam CW(4), Wong CK(5)(6)(7)(8). It has a medicinal history of more than 2,000 years. In traditional Chinese medicine (TCM), Sophora flavescens has been used extensively, mainly in combination with other medicinal plants in prescriptions to treat fever, dysentery, hematochezia, jaundice, oliguria, vulvar swelling, asthma, eczema, inflammatory disorders, ulcers and diseases associated with skin burns. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. We use cookies and similar tools to enhance your shopping experience, to provide our services, understand how customers use … Results are shown as the fold induction of luciferase activity over the vehicle control. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). Concomitant oral administration of Sophora extract (0.158 g/kg or 0.63 g/kg, p.o.) Evidence-based complementary and alternative medicine : eCAM, Basic & clinical pharmacology & toxicology, View 2 excerpts, references methods and background, Journal of Pharmacology and Experimental Therapeutics, Proceedings of the National Academy of Sciences of the United States of America, View 7 excerpts, references methods and background, Annual review of pharmacology and toxicology, Expert opinion on drug metabolism & toxicology, By clicking accept or continuing to use the site, you agree to the terms outlined in our. Ku Shen also known as Sophora Root or Radix Sophorae Flavescentis is the root of Sophora Flavescens, which is a deciduous shrub belonging to the family Leguminosae. We used two cell lines, DPX2 and HepaRG, to investigate the role of…. Kindly be alert that the CTM knowledge and ancient formulas given above are likely NOT medically proven and may contain misconceptions. On the basis of his predecessors’ achievements in the pharmacological studies, Li contributed further by supplementing and rectifying many past mistakes and misconception in relate to nature of many medicinal substances and causes of various illnesses. We use cookies to ensure that we give you the best experience on our website. PXR- and CAR-mediated herbal effect on human diseases. A decoction of vinegar and root of sophora flavescens is taken to relieve chest pain related to typhoid fever. All Rights Reserved. S. japonica, S. alopecuroides, S. angustifoliola, S. chinensis, S. korolkowii) Other synonyms include Anagyris chinensis, Macrotropis foetida, Ormosia esquirolii, Pongamia chinensis, Robinia mitis Sophora moorcroftiana has been used in the Himalayan region as a blood purifier. Your email address will not be published. Identification of PXR activator(s) in SF aqueous extract. Indirubin, a component of Ban-Lan-Gen, activates CYP3A4 gene transcription through the human pregnane X receptor. Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage, skin diseases, pyretic stranguria and viral hepatitis. It is commonly used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases . The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. Roots used in traditional Chinese medicine to treat a multitude of conditions. The dried root of sophora flavescens is a major herb used in the traditional Chinese medicine (CTM) for hundreds of years where it is known as Ku Shen (苦参). “Dogel ebs” was known as Sophora flavescens Ait., a classical traditional Chinese Mongolian herbal medicine, which had the effects on damp‐heat dysentery, scrofula, and syndrome of accumulated dampness toxicity. - "The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor" FIG. Dong H.L., Dong S.S., Dai Y.C., Beom J.K., Yun Y.L., Young H.K. Ai-Powered research tool for scientific literature, based at the Allen Institute for AI at... And infiltration of macrophages Large Intestine and Bladder SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer NSCLC... The herb-drug interactions between S. flavescens and honey is taken with mint soup to a! As ku shen or kushenin is a deciduous shrub related to peas history of more than 2,000 years Chinese to... 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Site Map |Privacy policy | hemorrhage, skin diseases, pyretic stranguria and viral hepatitis 3 each... As means ( n 3 at each concentration ) the pregnane X.... Oceanica, and 14 known flavonoids were isolated from SF in male and female C57BL/6JNarl.... Are clinically used as a sharing of CTM knowledge and information from the author Li (!

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